What effect do large doses of phenothiazines have?

Large doses of phenothiazines primarily function as tranquilizers. They are antipsychotic medications that work by blocking dopamine receptors in the brain, leading to a sedative effect. This tranquilizing effect is beneficial in managing severe anxiety, agitation, and psychotic disorders, making patients feel calmer and more stable.

While phenothiazines can also have antiemetic properties at certain doses, their primary effect in large doses tends to be sedation and tranquility. They are not known for stimulating effects, nor do they serve as antidepressants in the same way other medications specifically designed for depression do. Therefore, the tranquilizing effect is the most prominent and recognized characteristic when discussing the impact of large doses of phenothiazines.