Which medication is least likely to cause agranulocytosis?

Zoloft, which is the brand name for sertraline, is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class. It is generally considered to have a favorable safety profile and is not commonly associated with agranulocytosis, a potentially life-threatening condition characterized by a dangerously low level of neutrophils, which are vital for fighting infections.

In contrast, medications like clozapine are well-known for their association with agranulocytosis, leading to strict monitoring requirements due to this serious side effect. Other antipsychotics such as risperidone and olanzapine, while less commonly linked to agranulocytosis compared to clozapine, still have a risk, albeit lower. This makes Zoloft the medication least likely to cause this condition, emphasizing its safer profile regarding blood dyscrasias compared to the others listed.