Which of the following is a known toxic effect of aminoglycosides?

Aminoglycosides are a class of antibiotics known for their effectiveness against certain infections, particularly those caused by gram-negative bacteria. However, one of the significant toxic effects associated with aminoglycosides is ototoxicity.

Ototoxicity refers to damage to the inner ear structures, which can result in hearing loss or balance issues. This is especially important to monitor in patients receiving aminoglycosides because the risk for ototoxicity increases with higher doses or prolonged use of these medications. Patients may report symptoms such as ringing in the ears (tinnitus), dizziness, or hearing impairment.

Understanding ototoxicity is crucial for healthcare providers as they assess a patient's renal function and other medications to prevent exacerbating this side effect. Regular audiometric testing may be indicated for patients on long-term aminoglycoside therapy in order to detect any changes in hearing early.